safetyriskБезопасность и риск фармакотерапииSafety and Risk of Pharmacotherapy2312-78212619-1164Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)10.30895/2312-7821-2018-6-2-68-77safetyrisk-103Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESОБЗОР СЛУЧАЕВ РАЗВИТИЯ ОСТРОЙ ПЕЧЕНОЧНОЙ НЕДОСТАТОЧНОСТИ ВСЛЕДСТВИЕ ПРИЕМА БИОЛОГИЧЕСКИ АКТИВНЫХ ДОБАВОКA REVIEW OF CASES OF DEVELOPMENT OF ACUTE HEPATIC INSUFFICIENCY DUE TO THE INTAKE OF BIOLOGICALLY ACTIVE ADDITIVESМаксимовМ. Л.MaksimovM. L.

Максимов Максим Леонидович. Заведующий кафедрой клинической фармакологии и фармакотерапии КГМА;  ведущий аналитик отдела методологии экспертного анализа Управления экспертизы безопасности лекарственных средств ФГБУ «НЦЭСМП». доктор медицинских наук. профессор 

ул. Муштари, д. 11, г. Казань, 420012

Maksimov Maxim L. Head of the Department of Clinical Pharmacology and Pharmacotherapy. MD, DSc (Med), Assoc. prof.; Leading Analyst of Department of Expert Analysis Methodology of the DEMPS.

Mushtari str, 11, Kazan, 420012

Maximov@expmed.ruСимаковаС. А.SimakovaS. A.

Симакова Светлана Алексеевна. Ассистент кафедры клинической фармакологии и фармакотерапии. 

ул. Муштари, д. 11, г. Казань, 420012

Simakova Svetlana A. Assistant of the Department of Clinical Pharmacology and Pharmacotherapy.

Mushtari str, 11, Kazan, 420012

Казанская государственная медицинская академия — филиал федерального государственного бюджетного образовательного учреждения дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации; 2 Федеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииРоссияKazan State Medical Academy — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuous Professional Education» of the Ministry of Healthcare of the Russian Federation; Scientific Centre for Expert Evaluation of Medicinal ProductsRussian FederationКазанская государственная медицинская академия — филиал федерального государственного бюджетного образовательного учреждения дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской ФедерацииРоссияKazan State Medical Academy — Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuous Professional Education» of the Ministry of Healthcare of the Russian FederationRussian Federation201821062018626877Copyright © Максимов М.Л., Симакова С.А., 20182018Максимов М.Л., Симакова С.А.Maksimov M.L., Simakova S.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.risksafety.ru/jour/article/view/103

Во всем мире распространено применение биологически активных добавок, которые общедоступны и могут быть приобретены без консультации с лечащим врачом. Считается, что более 50 % взрослого населения во всем мире используют биологически активные добавки. В статье рассмотрены вопросы регламентации рынка биологически активных добавок во всем мире, в том числе Российской Федерации, безопасность применения, развитие нежелательных реакций. Проведен поиск информации по базам данных о развитии лекарственных повреждений печени, связанных с применением биологически активных добавок, содержащих экстракт зеленого чая, усниновую кислоту, 1,3-диметиламиламин, витамин А, анаболические андрогенные стероиды, линолевую кислоту, эфедру, гарцинию камбоджу, используемых для снижения веса. При применении анаболических стероидов выявлен повышенный риск развития нежелательных реакций со стороны печени, сердечно-сосудистой и эндокринной систем. Применение БАД, содержащих экстракт зеленого чая, может привести к тяжелому поражению печени. Анализ нежелательных реакций после применения БАД под торговым названием Гербалайф выявил случаи фальсификации препаратов. Применение препаратов, содержащих витамин А в высоких дозах, эфедру, гарцинию камбоджу приводило к повышению печеночных трансаминаз, психических расстройств, остеопорозу, анорексии.

Around the world, the use of dietary supplements is common and can be purchased without consulting a doctor. It is believed that more than 50 % of adults worldwide use dietary supplements. The article deals with the regulation of the market of biologically active additives worldwide, including the Russian Federation, the safety of use, the development of undesirable reactions. Information was searched on databases on the development of medicinal liver damage associated with the use of biologically active additives containing green tea extract, usninic acid, 1,3-dimethylamylamine, vitamin A, anabolic androgenic steroids, linoleic acid, ephedra, Garcinia Cambogia used for weight loss. The use of anabolic steroids has revealed an increased risk of adverse reactions from the liver, cardiovascular and endocrine systems. The use of dietary supplements containing green tea extract can lead to severe liver damage. Analysis of adverse reactions after the use of dietary supplements under the trade name Herbalife revealed cases of falsification of drugs. The use of drugs containing vitamin a in high doses, ephedra, Garcinia Cambogia led to increased hepatic transaminases, mental disorders, osteoporosis, anorexia.

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The authors declare that there are no conflicts of interest present.