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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">safetyrisk</journal-id><journal-title-group><journal-title xml:lang="ru">Безопасность и риск фармакотерапии</journal-title><trans-title-group xml:lang="en"><trans-title>Safety and Risk of Pharmacotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2312-7821</issn><issn pub-type="epub">2619-1164</issn><publisher><publisher-name>Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30895/2312-7821-2018-6-4-174-179</article-id><article-id custom-type="elpub" pub-id-type="custom">safetyrisk-129</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Нефармакологические методы лечения как способ повышения безопасности фармакотерапии и профилактики полипрагмазии у пациентов старше 60 лет</article-title><trans-title-group xml:lang="en"><trans-title>Non-pharmacological Approaches to Treatment of Patients over 60 Years as a Way to Improve Pharmacotherapy Safety and Prevent Polypharmacy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7168-3636</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Переверзев</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Pereverzev</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, научный сотрудник лаборатории гериатрии ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России ОСП РГНКЦ, член Российской ассоциации геронтологов и гериатров (РАГГ)</p></bio><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Researcher of the Geriatrics Laboratory of the Pirogov Russian National Research Medical University, Russian Clinical and Research Center of Gerontology, member of the Russian Association of Gerontologists and Geriatricians (RAGG)</p></bio><email xlink:type="simple">acchirurg@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4193-688X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачева</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkacheva</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., директор ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России ОСП РГНКЦ, главный внештатный специалист-гериатр Минздрава России, президент РАГГ</p></bio><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor, Head of the Pirogov Russian National Research Medical University, Russian Clinical and Research Center of Gerontology, Chief Specialist — geriatrician of the Ministry of Health of Russia, President of RAGG</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1628-5093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котовская</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotovskaya</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., заместитель директора по научной работе ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России ОСП РГНКЦ, член РАГГ, член расширенного правления Европейского общества гериатрической медицины</p></bio><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor, Deputy Director for Science of the Pirogov Russian National Research Medical University, Russian Clinical and Research Center of Gerontology, member of RAGG, full board member of the European Geriatric Medicine Society</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0556-1697</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Онучина</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Onuchina</surname><given-names>Yu. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-эндокринолог, ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России ОСП РГНКЦ</p></bio><bio xml:lang="en"><p>MD, Endocrinologist of Pirogov Russian National Research Medical University, Russian Clinical and Research Center of Gerontology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7891-6850</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дудинская</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dudinskaya</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, заведующая лабораторией возрастных метаболических эндокринных нарушений, ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России ОСП РГНКЦ</p></bio><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Head of the laboratory of age-related metabolic endocrine disorders of the Pirogov Russian National Research Medical University, Russian Clinical and Research Center of Gerontology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8353-3165</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., заведующий лабораторией заболеваний костномышечной системы ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России ОСП РГНКЦ</p></bio><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor, Head of the laboratory of diseases of the musculoskeletal system of Pirogov Russian National Research Medical University, Russian Clinical and Research Center of Gerontology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования&#13;
«Российский национальный исследовательский медицинский университет имени Н.И. Пирогова»&#13;
Министерства здравоохранения Российской Федерации, Обособленное структурное подразделение «Российский геронтологический научно-клинический центр», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Russian Clinical and Research Center of Gerontology, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>18</day><month>12</month><year>2018</year></pub-date><volume>6</volume><issue>4</issue><fpage>174</fpage><lpage>179</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Переверзев А.П., Ткачева О.Н., Котовская Ю.В., Онучина Ю.С., Дудинская Е.Н., Наумов А.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Переверзев А.П., Ткачева О.Н., Котовская Ю.В., Онучина Ю.С., Дудинская Е.Н., Наумов А.В.</copyright-holder><copyright-holder xml:lang="en">Pereverzev A.P., Tkacheva O.N., Kotovskaya Y.V., Onuchina Y.S., Dudinskaya E.N., Naumov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.risksafety.ru/jour/article/view/129">https://www.risksafety.ru/jour/article/view/129</self-uri><abstract><p>Резюме. Наблюдаемое в течение последних лет повышение возраста (старение) населения Земли связано, в том числе, с появлением новых эффективных и безопасных лекарственных средств (ЛС). Однако доступность на рынке высокоэффективных ЛС имеет и обратную сторону — появление нежелательных реакций. Одной из причин их развития являются межлекарственные взаимодействия — изменение эффективности и безопасности одного ЛС на фоне одновременного или последовательного использования с другим ЛС. Применение немедикаментозных способов лечения и профилактики заболеваний представляется особо актуальным для пациентов старшей возрастной группы, так как позволяет не только уменьшить лекарственную нагрузку, снизить риск развития побочных эффектов, но также улучшить состояние в случае наличия патологических изменений организма, для которых на данный момент отсутствует эффективная фармакотерапия и фармакопрофилактика. Цель работы: систематизация и анализ данных по нефармакологическим методам лечения для повышения безопасности фармакотерапии и предупреждения полипрагмазии у пациентов пожилого возраста путем информирования специалистов здравоохранения о немедикаментозных способах коррекции значимых гериатрических проблем. Представлены подходы к коррекции таких гериатрических проблем, как делирий, саркопения, болевой синдром, включающие когнитивный тренинг, физическую активность, диету, частую реориентировку пациентов, помещение пациентов в специально оборудованные комнаты («delirium room») и др. Применение нефармакологических подходов позволяет значительно повысить безопасность необходимой лекарственной терапии, снизить риски развития нежелательных реакций, улучшить прогноз и качество жизни, а также эффективно бороться с полипрагмазией у пациентов старшей возрастной группы.</p></abstract><trans-abstract xml:lang="en"><p>Abstract. The demographic aging of the population of the earth observed in recent years is associated, inter alia, with the advent of new effective and safe medicines. However, the availability of highly effective drugs on the market also has a reverse side — the appearance of adverse drug reactions (ADRs), in particular as a result of drug-drug interactions. The use of non-pharmacological methods of treatment and prevention of diseases seems particularly relevant for patients of the older age group, as it allows not only to reduce the drug burden, to reduce the risk of ADRs but also to improve the patient’s state in case of diseases that have no effective pharmacotherapy and pharmacological prophylaxis. The aim of the study was to systematize and analyze data on non-pharmacological treatment methods in order to increase the safety of pharmacotherapy and prevent polypragmasia in elderly patients by informing health care providers about non-drug methods of correcting significant geriatric problems. The approaches to the correction of some major geriatric problems (delirium, sarcopenia, pain syndrome), including cognitive training, physical activity, diet, frequent reorientation of patients, placement of patients in specially equipped rooms («delirium room») were presented. The use of non-pharmacological approaches can significantly improve the safety of drug therapy, reduce the risks of ADRs, improve the patient’s prognosis and quality of life, and also effectively prevent polypharmacy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фармакотерапия</kwd><kwd>профилактика</kwd><kwd>оптимизация терапии</kwd><kwd>полипрагмазия</kwd><kwd>пожилые пациенты</kwd><kwd>делирий</kwd><kwd>саркопения</kwd><kwd>болевой синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pharmacotherapy</kwd><kwd>prophylaxis</kwd><kwd>optimization of therapy</kwd><kwd>polypharmacy</kwd><kwd>elderly patients</kwd><kwd>delirium</kwd><kwd>sarcopenia</kwd><kwd>pain syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ilango S, Pillans P, Peel NM, Scott I, Gray LC, Hubbard RE. 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