safetyriskБезопасность и риск фармакотерапииSafety and Risk of Pharmacotherapy2312-78212619-1164Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)10.30895/2312-7821-2019-7-3-139-145safetyrisk-148Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESОпиоиды и мигрень: частота употребления и информированность о применении опиоидов у турецких пациентов с мигреньюOpioids and Migraine: Opioid Awareness and Frequency of Use among Turkish Migraineurshttps://orcid.org/0000-0001-5309-1258ЭртемД. Х.ErtemD. H.

Девримсель Харика Эртем, MD

пр-т Халаскаргази, ул. Этфал, р-н Шишли, Стамбул, 34371, Турция

Devrimsel Harika Ertem, MD

Halaskargazi Cad., Etfal Sk., Sisli, Istanbul 34371, Turkey

hkaozhan@gmail.comhttps://orcid.org/0000-0002-5044-9573БасарирД. И.BasarirC. I.

Джелал Илькер Басарир, MD

пр-т Халаскаргази, ул. Этфал, р-н Шишли, Стамбул, 34371, Турция

Celal Ilker Basarir, MD

Halaskargazi Cad., Etfal Sk., Sisli, Istanbul 34371, Turkey

drilkerbasarir@gmail.comhttps://orcid.org/0000-0002-6369-7218БаранГ.BaranG.

Гезде Баран, MD

б-р Аднан Мендерес (пр-т Ватан), р-н Фатих, Стамбул, 34093, Турция

Gozde Baran, MD

Adnan Menderes Bulvarı (Vatan Cad.), Fatih, Istanbul 34093, Turkey

drgozdebaran@gmail.comhttps://orcid.org/0000-0002-0739-1687ГендертенН.GondertenN.

Нихал Гендертен, MD

пр-т Халаскаргази, ул. Этфал, р-н Шишли, Стамбул, 34371, Турция

Nihal Gonderten, MD

Halaskargazi Cad., Etfal Sk., Sisli, Istanbul 34371, Turkey

nihalgonderten@yahoo.com.trhttps://orcid.org/0000-0001-5045-7082ИликФ.IlikF.

Фаик Илик, MD

округ Мусалла Баглары, ул. Гюрз, д. 1, р-н Сельчуклу, Конья, 42060, Турция

Faik Ilik, MD

Musalla Baglari, Gurz St. N. 1, Selcuklu, Konya 42060, Turkey

faikilik@hotmail.comМедико-санитарный университет, Научно-исследовательский и подготовительный медицинский центр Шишли Хамидие Этфал, отделение неврологииТурцияUniversity of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Department of NeurologyTurkeyМедико-санитарный университет, Научно-исследовательский и подготовительный медицинский центр Шишли Хамидие Этфал, отделение неврологииТурцияUniversity of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Department of NeurologyTurkeyУниверситет Безмиалем Вакиф, медицинский факультет, отделение неврологииТурцияBezmialem Vakif University, Faculty of Medicine, Department of NeurologyTurkeyУниверситет КТО Каратай, медицинский факультет Медикана, филиал сети клиник МедиканаТурцияKTO Karatay University, Medicana Faculty of Medicine affi liated Konya Medicana Hospital, Department of NeurologyTurkey20191807201973139145Copyright © Эртем Д.Х., Басарир Д.И., Баран Г., Гендертен Н., Илик Ф., 20192019Эртем Д.Х., Басарир Д.И., Баран Г., Гендертен Н., Илик Ф.Ertem D.H., Basarir C.I., Baran G., Gonderten N., Ilik F.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.risksafety.ru/jour/article/view/148

Несмотря на неочевидные доказательства эффективности и безопасности применения препаратов опиоидов для лечения мигрени, пациентам с головной болью от умеренной до тяжелой степени в качестве обезболивающей терапии могут быть назначены опиоиды. Однако при применении опиоидов возможно развитие таких серьезных нежелательных реакций, как инвалидизирующая головная боль, сопутствующие психиатрические и сердечно-сосудистые заболевания. Снижение риска злоупотребления опиоидами и предотвращение опиоидной эпидемии является актуальной задачей здравоохранения. Цель работы: оценка информированности пациентов на территории Турции о возможности назначения опиоидной терапии при мигрени и частоты ее использования у пациентов с эпизодической и хронической мигренью. Материалы и методы. В исследование были включены пациенты с рецидивирующей мигренью. Для оценки информированности пациентов о возможности использования опиоидов при мигрени была разработана и использована полуструктурированная анкета. Результаты. Исследование охватило 102 пациента, из них 72 – с эпизодической мигренью и 30 – с хронической. Все пациенты сообщили, что врачи общей практики и неврологи не предлагали и не назначали им опиоидные препараты при мигрени. Кроме того, только 7 % пациентов заявили, что слышали о возможности терапии мигрени опиоидными препаратами, но они никогда не консультировались с лечащими врачами о нежелательных реакциях при назначении опиоидов. Выводы: результаты исследования свидетельствуют, что на территории Турции препараты опиоидов не были предпочтительным вариантом выбора для лечения приступов мигрени и их профилактики как для врачей, так и для пациентов. Ограничение назначения опиоидов способствует предотвращению развития чрезмерного употребления лекарств, наркомании, а также тяжелого побочного действия – головных болей, вызванных опиоидами.

Despite the inadequate evidence of effi cacy and safety of opioid use for the treatment of migraine, it has been reported that patients with moderate to severe migraine headaches are prescribed opioids. Migraineurs may experience serious health impacts from opioids such as headache-related disability, psychiatric and cardiovascular comorbidities. The reduction of the risk of opioid abuse and prevention of an opioid epidemic are important public health challenges. The aim of this study was to assess the awareness of opioid therapy for migraine and the frequency of use among Turkish patients with episodic and chronic migraine. Materials and methods: consecutive migraine patients were enrolled in this cross-sectional study. A semi-structured questionnaire was developed and used by the researchers to assess the patients’ awareness of an opiod treatment option and the frequency of use of opioids for migraine treatment. Results. One hundred two patients were enrolled, of which 72 had episodic migraine and 30 had chronic migraine. All subjects reported that they had not been offered or prescribed any kind of opioids by general practitioners and neurologists for their headache. Besides, only 7 % of patients declared that they had heard of opioid treatment for migraine but they had never consulted their doctors about its effects. Conclusions. Our fi ndings demonstrated that opioids were not preferred as an option for acute or preventive migraine treatment by Turkish migraineurs and their physicians. The reduction of opioid prescription will help to prevent the development of medication overuse and opiate-induced headaches and drug addiction.

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The authors declare that there are no conflicts of interest present.