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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">safetyrisk</journal-id><journal-title-group><journal-title xml:lang="ru">Безопасность и риск фармакотерапии</journal-title><trans-title-group xml:lang="en"><trans-title>Safety and Risk of Pharmacotherapy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2312-7821</issn><issn pub-type="epub">2619-1164</issn><publisher><publisher-name>Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">safetyrisk-292</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Миотоксичность местных анестетиков</article-title><trans-title-group xml:lang="en"><trans-title>LOCAL ANESTHETIC MYOTOXICITY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романов</surname><given-names>Б. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanov</surname><given-names>B. K.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Переверзев</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Pereverzev</surname><given-names>A. P.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironov</surname><given-names>A. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бунятян</surname><given-names>Н. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Bunyatyan</surname><given-names>N. D.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лепахин</surname><given-names>В. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Lepakhin</surname><given-names>V. K.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение&#13;
«Научный центр экспертизы средств медицинского применения»&#13;
Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Centre for Expert Evaluation of Medicinal Products&#13;
Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>05</month><year>2022</year></pub-date><volume>0</volume><issue>1</issue><fpage>18</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Романов Б.К., Переверзев А.П., Миронов А.Н., Бунятян Н.Д., Лепахин В.К., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Романов Б.К., Переверзев А.П., Миронов А.Н., Бунятян Н.Д., Лепахин В.К.</copyright-holder><copyright-holder xml:lang="en">Romanov B.K., Pereverzev A.P., Mironov A.N., Bunyatyan N.D., Lepakhin V.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.risksafety.ru/jour/article/view/292">https://www.risksafety.ru/jour/article/view/292</self-uri><abstract><p>В статье представлены механизмы развития и методы коррекции миотоксичности при применении местных анестетиков.</p></abstract><trans-abstract xml:lang="en"><p>The article presents the mechanisms of development and methods of correction of myotoxicity associated with use of local anesthetics</p></trans-abstract><kwd-group xml:lang="ru"><kwd>местные анестетики</kwd><kwd>мышечный некроз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>local anesthetics</kwd><kwd>muscle necrosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Denkler K. 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