safetyriskБезопасность и риск фармакотерапииSafety and Risk of Pharmacotherapy2312-78212619-1164Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)safetyrisk-36Research ArticleОБЗОРЫ И ОРИГИНАЛЬНЫЕ СТАТЬИREVIEWS AND ORIGINAL ARTICLESРиск развития лекарственных взаимодействий при применении молочного чертополоха (расторопши)The risk of milk thistle (Silybum marianum) drug interactionsКазаковА. С.KazakovA. S.noemail@neicon.ruЗатолочинаК. Э.ZatolochinaK. E.noemail@neicon.ruКолесниковаЕ. Ю.KolesnikovaE. Yu.noemail@neicon.ruЖуравлеваЕ. О.ZhuravlevaO. E.noemail@neicon.ruНаучный центр экспертизы средств медицинского примененияРоссияScientific Centre for Expert Evaluation of Medicinal ProductsRussian Federation201620022018013337Copyright © Казаков А.С., Затолочина К.Э., Колесникова Е.Ю., Журавлева Е.О., 20182018Казаков А.С., Затолочина К.Э., Колесникова Е.Ю., Журавлева Е.О.Kazakov A.S., Zatolochina K.E., Kolesnikova E.Y., Zhuravleva O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.risksafety.ru/jour/article/view/36

Молочный чертополох (Расторопша пятнистая) является широко используемым растительным препаратом, который обладает относительно низким риском развития лекарственных взаимодействий. Вместе с тем, в литературе имеются указания о возможном влиянии препаратов расторопши на активность микросомальных ферментов и р-гликопротеина. Противоречивость данных обусловленв различиями протоколов исследований. Наличие в базах данных описаний случаев лекарственного взаимодействия с участием расторопши предполагает возможное клинически значимое влияние на активность ферметов цитохрома Р450.

Milk Thistle (Silybum marianum) is a widely used herbal remedy, which has a relatively low risk of drug interactions. However, there is evidence in the literature about the possible impact of thistle drugs on activity of microsomal enzymes and p-glycoprotein. Contradictory data depends on differences in study protocols. The existence in the database case reports of drug interactions with milk thistle suggests a possible clinically significant effect on the activity of cytochrome P450 enzymes.

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The authors declare that there are no conflicts of interest present.