safetyriskБезопасность и риск фармакотерапииSafety and Risk of Pharmacotherapy2312-78212619-1164Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)10.30895/2312-7821-2023-11-4-409-422safetyrisk-387Research ArticleГЛАВНАЯ ТЕМА: ИСКУССТВЕННЫЙ ИНТЕЛЛЕКТ В ЗДРАВООХРАНЕНИИ: ПОЛЬЗА И РИСКИMAIN TOPIC: ARTIFICIAL INTELLIGENCE IN HEALTHCARE: RISKS AND BENEFITSЦифровое сопровождение фармакотерапии для соблюдения режима приема лекарственных препаратовDigital Pharmacotherapy Support for Medication Adherencehttps://orcid.org/0009-0004-1068-8088ЗаверячевС. А.ZaveryachevS. A.

Заверячев Станислав Артемович

ул. Трубецкая, д. 8, стр. 2, Москва, 119991

Stanislav A. Zaveryachev

8/2 Trubetskaya St., Moscow 119991

 

szaver4@gmail.comhttps://orcid.org/0009-0006-0132-106XЛотникЕ. Е.LotnikE. E.

Лотник Екатерина Евгеньевна

ул. Трубецкая, д. 8, стр. 2, Москва, 119991

Ekaterina E. Lotnik

8/2 Trubetskaya St., Moscow 119991lotnikk@mail.ruhttps://orcid.org/0009-0002-3078-6270ГилавянМ. А.GilavyanM. A.

Гилавян Мариам Артуровна

ул. Трубецкая, д. 8, стр. 2, Москва, 119991

Mariam A. Gilavyan

8/2 Trubetskaya St., Moscow 119991m.gilavyan@yandex.ruhttps://orcid.org/0009-0005-0327-7050ЮсуповскаяЕ. А.YusupovskayaE. A.

Юсуповская Елена Александровна

ул. Трубецкая, д. 8, стр. 2, Москва, 119991

Elena A. Yusupovskaya

8/2 Trubetskaya St., Moscow 119991darkblueberrypie@gmail.comhttps://orcid.org/0000-0001-7309-2215КошечкинК. А.KoshechkinK. A.

Кошечкин Константин Александрович, д-р фарм. наук, профессор

ул. Трубецкая, д. 8, стр. 2, Москва, 119991

Konstantin A. Koshechkin

8/2 Trubetskaya St., Moscow 119991koshechkin_k_a@staff.sechenov.ruФедеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет им. И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202317102023114409422Copyright © Заверячев С.А., Лотник Е.Е., Гилавян М.А., Юсуповская Е.А., Кошечкин К.А., 20232023Заверячев С.А., Лотник Е.Е., Гилавян М.А., Юсуповская Е.А., Кошечкин К.А.Zaveryachev S.A., Lotnik E.E., Gilavyan M.A., Yusupovskaya E.A., Koshechkin K.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.risksafety.ru/jour/article/view/387Актуальность

Актуальность. Соблюдение режима приема лекарственных препаратов (ЛП) является одним из важных условий эффективного и безопасного лечения. Контроль выполнения назначений проводят путем оценки врачом динамики состояния пациента, путем подсчета принятых таблеток и другими косвенными методами. Для увеличения приверженности пациентов к соблюдению режима приема ЛП возможно использование цифровых технологий.

Цель

Цель. Провести обзор данных литературы о влиянии режима приема лекарственных препаратов на их эффективность и о цифровых решениях для сопровождения фармакотерапии.

Обсуждение

Обсуждение. Низкая приверженность лечению — значимый фактор риска для пациентов. Показано, что наиболее распространенными нарушениями являются пропуск или несвоевременный прием ЛП, а риск ошибок значительно повышается при применении ЛП по индивидуальной схеме по сравнению с классическим вариантом ежедневного приема. Среди значимых последствий нарушения режима приема препарата — обострение заболевания, недостаточная эффективность лечения, развитие нежелательных реакций, лекарственная устойчивость. Перспективными техническими и программными подходами, позволяющими оказать поддержку пациенту для соблюдения режима приема ЛП, являются инновационные технологические решения (таблетницы, флаконы с электронными системами напоминания о времени приема ЛП, цифровые таблетки, интеллектуальные системы контроля приема препаратов), приложения для мобильных телефонов, чат-боты.

Выводы

Выводы. Показано, что использование цифровых решений для сопровождения фармакотерапии приводит к повышению приверженности пациентов к соблюдению режима приема ЛП и позволяет индивидуализировать схему терапии. Для выбора наиболее перспективных направлений и разработки новых цифровых технологий для контроля фармакотерапии необходимо проведение дальнейших исследований.

Scientific relevance

Scientific relevance. Medication adherence is an important condition for effective and safe treatment. The adherence of patients to prescriptions is tracked by assessing their condition, counting the pills taken, and using other indirect methods. Digital technologies can help healthcare providers improve their patients’ medication adherence.

Aim

Aim. The authors aimed to review literature describing the medication adherence impact on treatment effectiveness, as well as digital solutions accompanying pharmacotherapy.

Discussion

Discussion. Poor adherence to treatment is a significant risk factor for patients. The most common examples of poor adherence are omissions and delays in the timing of doses. Compared with classical daily dosing, individualised regimens significantly increase the risk of adherence errors. Significant consequences of non-adherence include exacerbation of the disease, insufficient effectiveness of treatment, adverse drug reactions, and drug resistance. Promising hardware and software approaches to supporting medication adherence include innovative technological solutions (pillboxes, bottles with electronic reminder systems, digital pills, and smart medication adherence monitoring systems), mobile apps, and chatbots.

Conclusions

Conclusions. Digital solutions to support pharmacotherapy help improve patients’ adherence to their dosing regimens and individualise their treatment. Further research is needed to select the most promising areas and develop novel digital technologies.

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The authors declare that there are no conflicts of interest present.