safetyriskБезопасность и риск фармакотерапииSafety and Risk of Pharmacotherapy2312-78212619-1164Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)safetyrisk-50Research ArticleОБЗОРЫ И ОРИГИНАЛЬНЫЕ СТАТЬИREVIEWS AND ORIGINAL ARTICLESФизостигмин как антиноцицептивное средство: возможный путь повышения безопасности анестезиологического пособияPhysostigmine as an antinociceptive agent: a possible way to improve the safety of anesthesiaНемировскийА. .NemirovskyA. .noemail@neicon.ruКалифорнийский университетРоссияUniversity of California at Los-AngelesRussian Federation201620022018032227Copyright © Немировский А..., 20182018Немировский А...Nemirovsky A...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.risksafety.ru/jour/article/view/50

Создание новых безопасных анальгетических средств является актуальной задачей, решение которой позволит повысить эффективность анестезиологического пособия. Целью настоящего исследования явилось изучение анальгетического действия физостигмина, вводимого интратекально. Антиноцицептивное действие оценивалось с помощью метода «плантарной» стимуляции. Физостигмин при этом пути введения проявлял анальгетическое действие в раннем послеоперационном периоде. Действие физостигмина может быть обусловлено влиянием на спинальные звенья системы контроля афферентного входа.

Search for new safe analgesics is an urgent task that will increase the safety and efficiency of anesthesia. The aim of this study was to investigate the analgesic effect of intrathecally administered physostigmine. Antinociceptive effect was evaluated by using the method «plantar» stimulation. Administered intrathecally physostigmine caused analgesic action in the early postoperative period. Efficiency of physostigmine may be due to the influence on cholinergic links of afferent gate control system at spinal level.

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The authors declare that there are no conflicts of interest present.