safetyriskБезопасность и риск фармакотерапииSafety and Risk of Pharmacotherapy2312-78212619-1164Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)safetyrisk-63Research ArticleОБЗОРЫ И ОРИГИНАЛЬНЫЕ СТАТЬИREVIEWS AND ORIGINAL ARTICLESИнгибиторы ко-транспортеров SGLT-2: контроль уровня гликемии и нефропротективные свойстваSGLT2 inhibitors: control of glycemia and nephroprotection propertiesВолодинА. А.VolodinA. A.noemail@neicon.ruМаксимовМ. Л.MaximovM. L.noemail@neicon.ruСлободянВ. Г.SlobodyanV. G.noemail@neicon.ruАляутдинР. Н.AlyautdinR. N.noemail@neicon.ruПервый Московский государственный медицинский университет имени И. М. СеченоваРоссияI. M. Sechenov First Moscow State Medical UniversityRussian FederationНаучный центр экспертизы средств медицинского примененияРоссияScientific Centre for Expert Evaluation of Medicinal ProductsRussian Federation201720022018511126Copyright © Володин А.А., Максимов М.Л., Слободян В.Г., Аляутдин Р.Н., 20182018Володин А.А., Максимов М.Л., Слободян В.Г., Аляутдин Р.Н.Volodin A.A., Maximov M.L., Slobodyan V.G., Alyautdin R.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.risksafety.ru/jour/article/view/63

Несколько лет назад появился принципиально новый инсулиннезависимый подход к лечению СД 2 - снижение уровня гликемии путем ингибирования белков ко-транспортеров SGLT-2 (sodium glucose transporter) в проксимальных канальцах почек, которые отвечают за обратную реабсорбцию глюкозы. ЛС группы ингибиторов SGLT-2 ко-транспортеров эффективны как в режиме монотерапии, так и в комбинации с другими сахароснижающими препаратами. При этом, по результатам проведенных рандомизированных контролируемых клинических исследований, терапия данным классом ЛС хорошо переносилась. Частота случаев гипогликемии статистически не отличалась от частоты случаев гипогликемии в группе плацебо. На фоне терапии наблюдалось стабильное снижение массы тела у пациентов с СД 2 типа. Терапия ЛС класса ингибиторов SGLT-2 ко транспортеров сопровождалась снижением артериального давления и массы тела. Данный класс ЛС может играть потенциально важную роль на ранних этапах развития диабетической нефропатии, обладая потенциальным нефропротективным действием, работая на уровне снижения внутриклубочкового давления одного нефрона. Инсулиннезависимый механизм действия и низкий риск гипогликемии делает ингибиторы SGLT-2 ко-транспортеров эффективным и безопасным дополнением к существующим методам контроля уровня гликемии у больных СД 2 типа.

Recently were appeared a fundamentally new insulin-independent approach to the treatment of type 2 diabetes - reduce blood glucose levels by inhibiting proteins co-transporters SGLT2 (sodium glucose transporter) in the proximal tubules of the kidneys, which are responsible for the reabsorption of glucose. Inhibitors SGLT2 co-transporters is effective either as monotherapy or in combination with other antidiabetic drugs. Thus, according to the results of randomized controlled trials, therapy with this class of drugs was well tolerated. The incidence of hypoglycemia was not statistically different from the incidence of hypoglycemia in the placebo group. On the background of therapy was observed a stable decrease in body weight in patients with type 2 diabetes. Therapy with all drugs of a class of SGLT2 inhibitors was accompanied by a decrease in blood pressure and body weight. This class of drugs could potentially play an important role in the early stages of development of diabetic nephropathy, with potential nephrorotective effect, working on the level of reduction intraglomerular pressure of a single nephron. Insulin-independent mechanism of action and low risk of hypoglycaemia makes the SGLT2 inhibitors effective and safe addition to existing methods of control glycemia in patients with type 2 diabetes.

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The authors declare that there are no conflicts of interest present.