safetyriskБезопасность и риск фармакотерапииSafety and Risk of Pharmacotherapy2312-78212619-1164Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)safetyrisk-81Research ArticleФАРМАКОЛОГИЯ, КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯPHARMACOLOGY, CLINICAL PHARMACOLOGYКонтроль за нежелательными реакциями при проведении антиретровирусной терапии ВИЧ/СПИД при применении взаимозаменяемых лекарственных препаратовControl of adverse drug reactions in HIV/AIDS antiretroviral treatment with interchangeable medicinesЖуравлеваМ. В.ZhuravlevaM. V.noemail@neicon.ruПрокофьевА. Б.ProkofievA. B.noemail@neicon.ruПодымоваА. С.PodymovaA. S.noemail@neicon.ruБердниковаН. Г.BerdnikovaN. G.noemail@neicon.ruСереброваС. Ю.SerebrovaS. Yu.noemail@neicon.ruДемченковаЕ. Ю.DemchenkovaE. Yu.noemail@neicon.ruНаучный центр экспертизы средств медицинского применения; Первый Московский государственный медицинский университет имени И. М. СеченоваРоссияScientific Centre for Expert Evaluation of Medicinal Products; I. M. Sechenov First Moscow State Medical UniversityRussian FederationНаучный центр экспертизы средств медицинского примененияРоссияScientific Centre for Expert Evaluation of Medicinal ProductsRussian FederationСвердловский областной центр профилактики и борьбы со СПИДРоссияSverdlovsk Regional AIDS Prevention and Control CenterRussian FederationПервый Московский государственный медицинский университет имени И. М. СеченоваРоссияI. M. Sechenov First Moscow State Medical UniversityRussian Federation20172002201853126132Copyright © Журавлева М.В., Прокофьев А.Б., Подымова А.С., Бердникова Н.Г., Сереброва С.Ю., Демченкова Е.Ю., 20182018Журавлева М.В., Прокофьев А.Б., Подымова А.С., Бердникова Н.Г., Сереброва С.Ю., Демченкова Е.Ю.Zhuravleva M.V., Prokofiev A.B., Podymova A.S., Berdnikova N.G., Serebrova S.Y., Demchenkova E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.risksafety.ru/jour/article/view/81

Представлен обзор данных по оценке нежелательных лекарственных реакций, которые необходимо контролировать при проведении антиретровирусной терапии у пациентов ВИЧ/СПИД. Особое значение вопросы безопасности лекарственных препаратов приобретают при проведении фармакотерапии наиболее социально значимых заболеваний, к которым относится ВИЧ/СПИД. В настоящее время имеется достаточное количество воспроизведенных препаратов для проведения антиретровирусной терапии, что является основой для обеспечения доступной медицинской помощи. При этом вопросы соотношения эффективности и безопасности воспроизведенных препаратов, оценки их взаимозаменяемости требуют постоянного изучения влияния антиретровирусных препаратов на различные системы организма. Особое внимание необходимо уделять осложнениям со стороны сердечно-сосудистой системы и вопросам гепатотоксичности.

Review on assessment data of ADR, which must be monitored during antiretroviral therapy in patients with HIV/AIDS are presented. Questions of drug safety acquire particular importance in conducting pharmacotherapy of the most socially significant diseases, which include HIV/AIDS. Currently there is a sufficient number of generic drugs for antiretroviral therapy, which form the basis for affordable health care. The correlation of efficacy and safety of generic drugs, their interchangeability assessment require constant study of the antiretroviral drugs influence on various systems of the body. Particular attention should be given to the cardiovascular disorders and hepatotoxicity.

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The authors declare that there are no conflicts of interest present.