On the safety of acetaminophen
Abstract
Acetaminophen is one of the most commonly used analgesics /
anti pyretics. However, taking into account the existing risk of hepatotoxicity,
regulatory bodies of a number of the countries made additional adjustments to
the recommendations on the use of this drug. In the article the possible reasons
for recourse to acetaminophen are discussed
About the Authors
R. N. Alyautdin
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
V. K. Lepakhin
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
B. K. Romanov
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
A. P. Pereverzev
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
References
1. http://www.fda.gov/Drugs/DrugSafety/ucm381644.htm.www.tga.gov.au
2. Toussaint K., Yang X.C., Zielinski M.A. What do we (not) know about how paracetamol
3. (acetaminophen) works? // J. Clin. Pharm. Ther. 2010. V. 35. P. 617–638
4. Hinz В., Cheremin a О., Brune К. Acetaminophen (paracetamol) is a selective cyclooxygen
5. ase-2 inhibitor in man. FASEB.// 2008. V. 22. P. 383-390
6. Oscier C.D., Milner O. Peri-operative use of paracetamol.// An aesthesia. 2009.V. 64. P.
7. –72
8. Pierre S.C., Schmidt R., BrenneisC., et al. Inhibition of Cyclooxygen ases by Di pyrone.//
9. Brit. J. Pharmacol. 2007. V.151. P. 494–503
10. Hanel AM, Lands WE. Modification of anti-inflammatory drug effectiveness by ambient
11. li pid peroxides. Biochem. Pharmacol.// 1982. V.33. P. 3307–3311.
12. Tjolsen A, Lund A, Hole K. Antinociceptive effect of paracetamol in rats is partly dependent
13. on spin al serotonergic systems.// Eur. J. Pharmacol. 1991.V.193. P.193–201.
14. Zygmunt PM, Chuang H, Movahed P, et al. The an andamide transport inhibitor AM404
15. activates vanilloid receptors.// Eur. J. Pharmacol. 2000.V.396. P.39–42.
16. Bjorkman R., Hallman K.M., Hedner T., Henning M. Acetaminophen blocks spin al hyperalgesia
17. induced by NMDA and substance P.// Pain. 1994. V.57. P.259–264.
18. Barden J., Edwards J., Moore A., McQuay H. Single dose oral paracetamol (acetaminophen)
19. for postoperative pain.// Cochrane Database of Systematic Rev. 2004. V. 1: CD004602.
20. Weil K, Hooper L, Afzal Z, et al. Paracetamol for pain relief after surgical removal of
21. lower wisdom teeth.// Cochrane Database of Systematic Rev. 2007. V. 3. CD004487.
22. Corcoran G.B., Racz W.J., Smith C.V. and Mitchel, J.R. Effects of N-acetylcysteine on
23. acetaminophen covalent binding and hepatic necrosis in mice.// J. Pharmacol. Exp. Ther.
24. V. 232. P. 864-872
25. Forrest J., Adriaenssens P., Finlayson N.D., Prescott L.F. Paracetamol metabolism in
26. chronic liver disease.// Eur. J. Clin. Pharmac. 1979.V. 15. P. 427–31.
27. Bertolini A., FerrariA., Ottani A.et al. Paracetamol: New Vistas of an Old Drug. CNS
28. Drug Reviews//. 2006. No. 3–4, 250-275
29. Smidt L.E., Dalhoff A. The effect of regular medication on the outcome of paracetamol
30. poisoning.// Aliment. Pharmacol. Ther. 2002.V. 1.P.: 1539–1545.
31. Sonne J., Poulsen H.E., Andreasen P.B. Single dose oxazepam has no effect on acetaminophen
32. clearance or metabolism.// Eur. J.Clin Pharmacol. 1986. V. 30.P. 127–129.
33. Skoulis N.P., James R.C., Harbison R.D., Roberts S.M. Depression of hepatic glutathione
34. by opioid an algesic drugs in mice.// Toxicol. Appl. Pharmacol. 1989. V. 99.P. 139–147.
35. Rumack B.H. Acetaminophen misconceptions//. Hepatology. 2004. V. 40.P. 10–15.
36. Draganov .P, Durrence H., Cox C., Reuben A. Alcoholacetaminophen syndrome. Even
37. moderate social drinkers are at risk.// Postgrad. Med. 2000. V.107. P. 189–195.
38. Kuffner EK, Dart RC, Bogdan GM, Hill RE, Casper E, Darton L. Effect of maximal daily
39. doses of acetaminophen on the liver of alcoholic patients: a randomized double-blind
40. placebo-controlled trial.// Arch. Intern. Med. 2001. V. 161. P. 2247–2252.
41. Heard K., Green J..L, Bailey J.E.et al. A randomized trial to determine the change in alanine
42. aminotransferase during 10 days of paracetamol (acetaminophen) administration in
43. subjects who consume moderate amounts of alcohol.// Alimentary Pharmac. Ther. 2007.
44. V. 26.P. 283–290.
45. Prescott.L.E. Paracetamol, alcohol and the liver.// Br. J. Clin. Pharmacol. 2006. V.49. P. 291-301
46. Lauterburg B.H., Velez M.E. Glutathione deficiency in alcoholics: Risk factor for paracetamol
47. hepatotoxicity.// Gut. 1988. V. 29. P.1153–1157.
48. Lauterburg B.H., Velez M.E. Glutathione deficiency in alcoholics: Risk factor for paracetamol
49. hepatotoxicity.// Gut. 1988. V. 29. P.1153–1157
Review
For citations:
Alyautdin R.N., Lepakhin V.K., Romanov B.K., Pereverzev A.P. On the safety of acetaminophen. Safety and Risk of Pharmacotherapy. 2014;(2):5-9. (In Russ.)
Views:
604
Email this article 