Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice
Abstract
Paclitaxel is an effective antitumor agent used for treatment of breast cancer, lung, stomach and pancreas. However, its own adverse effects and the use of toxic Cremophor EL as the solvent limit the application range of this drug. Associated with the albumin-bound nanoparticle paclitaxel (paclitaxel SAN) specifically transported into tumor tissue. This leads to an increase in the antitumor effect, and it reduces the severity of side effects.
About the Authors
R. N. Alyautdin
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
B. K. Romanov
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
В. К. Лепахин
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
N. D. Bunyatyan
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
V. A. Merkulov
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
A. N. Mironov
Scientific Centre for Expert Evaluation of Medicinal Products Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Alyautdin R.N., Romanov B.K., Лепахин В.К., Bunyatyan N.D., Merkulov V.A., Mironov A.N. Nanoparticle albumin-bound paclitaxel – first step of nanotechnology into clinical practice. Safety and Risk of Pharmacotherapy. 2014;(2):10-16. (In Russ.)
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