Psychotropic Agents, Statins, and Beta-Blockers in Pregnancy: A New Risk Factor for Autism Spectrum Disorders in Children (Analysis of a Retrospective RWD/RWE Study)
https://doi.org/10.30895/2312-7821-2026-14-2-127-130
Abstract
Editor-in-Chief of Safety and Risk of Pharmacotherapy Renad N. Alyautdin presents an analysis of the article “Sterol pathway disruption in pregnancy: A link to autism” (2026), published in Molecular Psychiatry, which reports the results of a large-scale retrospective RWD/RWE study of more than 6 million mother–child pairs (2014–2023). The study identifies an association between prenatal exposure to inhibitors of post-lanosterol cholesterol synthesis and the risk of autism spectrum disorder in children.
Keywords
pharmacovigilance,
antipsychotic agents,
statins,
beta-blockers,
pregnancy,
sterol homeostasis,
pharmacogenetics
Funding: The study was performed without external funding
About the Author
R. N. Alyautdin
Scientific Centre for Expert Evaluation of Medicinal Products;
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Renad N. Alyautdin, Dr. Sci. (Med.), Professor
8/2 Petrovsky Blvd., Moscow 127051;
2/4 Bolshaya Pirogovskaya St., Moscow, 119048
References
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Review
For citations:
Alyautdin R.N. Psychotropic Agents, Statins, and Beta-Blockers in Pregnancy: A New Risk Factor for Autism Spectrum Disorders in Children (Analysis of a Retrospective RWD/RWE Study). Safety and Risk of Pharmacotherapy. 2026;14(2):127-130. (In Russ.) https://doi.org/10.30895/2312-7821-2026-14-2-127-130
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