Sergey K. ZYRYANOV

Dr. Sci. (Med.), Full Professor

Head of the Department of General and Clinical Pharmacology of the Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, Russia

Research interests

Pharmacoepidemiological and pharmacoeconomic studies, elaboration of methodological foundations for the organisation of pharmacovigilance service, the efficacy and safety of new medicines.

Key research accomplishments

Sergey K. Zyryanov created a scientific school of specialists engaged in a new direction of clinical pharmacology – personalising the use of medicines in special patient populations and assessing the clinical and economic impact of their use. Under the leadership of Prof. S.K. Zyryanov, therapeutic pharmaceutical monitoring of medicines used in the therapy of premature newborns with very low and extremely low birth weight, as well as in elderly and senile patients, and dosing schemes of antibacterial drugs and anticonvulsants for such patients have been introduced into the practice of medical institutions. Based on the obtained data, a number of models of population pharmacokinetics in premature newborns have been developed and introduced into clinical practice. S.K. Zyryanov organised pharmacoepidemiological monitoring to assess the safety of medicines in elderly patients. The use of this technology made it possible to identify groups of medicines, the use of which in such patients is accompanied by the risk of serious adverse reactions. The introduction of these innovative technologies for diagnostics and treatment of therapeutic and paediatric patients into clinical practice helped to improve the quality of medical care and reduce in-hospital mortality.

The research group led by Professor S.K. Zyryanov is actively developing modern approaches to conducting molecular diagnostics of polymorphism of opioid analgesic biotransformation genes and studying its role in the modification variability of analgesia in clinical oncology. Innovative approaches to improving the efficacy and safety of anticonvulsant therapy based on the study of polymorphism of cytochrome P450 system genes and therapeutic medication monitoring have been developed.

Under guidance of Professor S.K. Zyryanov and counselling, 11 candidate and 5 doctoral theses were defended.

Publication activity

Author of more than 500 publications, co-author of 10 monographs, 22 educational and training manuals, and is a member of the author's team of Russian national guidelines (Clinical Pharmacology, 2009; Geriatrics, 2018). Under the editorship of S.K. Zyryanov, the first in the Russian Federation Formulary of Medicines in Palliative Medicine was prepared (2016). Author of 4 inventions and 2 rationalisation proposals.

Hirsch index: 21 (RSCI), 8 (Scopus).

Awards

Prof. S.K. Zyryanov is a holder of the Certificate of Honour of the Ministry of Health of the Republic of Bashkortostan (2001), the Certificate of Honour of the Higher Attestation Commission of the Russian Federation (2022), the Certificate of Honour of Peoples’ Friendship University of Russia named after Patrice Lumumba (2023), the Acknowledgement of the Mayor of Moscow (2020).

Public recognition of his services in the field of clinical pharmacology was expressed in the award of the Ministry of Health of the Russian Federation and Channel One “Prizvanie” to the best doctors of Russia in the nomination “For contribution to the development of medicine for representatives of fundamental science and non-medical professions” (2021). He is also a laureate of the National Award of the Russian Professors Assembly “Professor of the Year” in the nomination “Medical Sciences” (2021).

Membership on other editorial boards

Editor-in-Chief of Good Clinical Practice.
Member of Editorial Boards of Pharmateka, Pediatric Pharmacology.
Scientific Editor of Journal of Practical Pulmonology.

Membership on organisations

Member of the Profile Commission of the Ministry of Health of the Russian Federation on clinical pharmacology; Member of the Expert Council of the Higher Attestation Commission of the Russian Federation on therapeutic sciences.

Actively participates in the International Society for Pharmacoeconomics and Outcomes Research, European Respiratory Society, Russian Society of Clinical Researchers, Russian Interregional Society of Pharmacoeconomic Research, Interregional Association of Clinical Microbiologists and Antimicrobial Chemotherapists, Russian Scientific Medical Society of Therapists. Member of the Interregional Public Organisation Association of Clinical Pharmacologists, member of the working group of experts on pharmacoeconomics, member of the Presidium of the Profile Councils on pulmonology and rheumatology.