ADVERSE EVENTS OF INTERFERONS WITH SYSTEMIC EFFECT
Abstract
Objective: To explore the profile of adverse events associated with interferon therapy. Design: Systematic review. Data sources: Electronic and paper records in subject area from 2000 to 2014. Methods: We searched for the studies on safety and tolerability containing adverse events of interferons with systemic effect. Results: The most frequent adverse events were: flu-like syndrome (55%), depression (30%), neutropenia (20%), anemia (13%). Conclusion: Adverse events are a very serious problem of interferon treatment. System of pharmacovigilance provides forecasting and early identification of these adverse events, as they are predictable.
About the Authors
A. A. Toporov
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
A. S. Kolbin
Pavlov First Saint Petersburg State Medical University; Saint Petersburg State University
Russian Federation
Russian Federation
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Review
For citations:
Toporov A.A., Kolbin A.S. ADVERSE EVENTS OF INTERFERONS WITH SYSTEMIC EFFECT. Safety and Risk of Pharmacotherapy. 2015;(2):5-11. (In Russ.)
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