ON THE SAFETY OF ANTIBACTERIAL DRUGS USED IN PEDIATRICS
Abstract
The safety of application of different groups of antibacterial drugs in pediatrics among children is discussed in this article. The analysis was made of spontaneous reports in the national database for 2012, containing information about serious adverse reactions (AR) on antibiotics in the pediatric population. In addition to evaluating the overall structure of serious AR and their distribution to system organ classes, the role of different pharmaco-therapeutic groups of antibacterial drugs in the development of adverse effects of pharmacotherapy was analyzed. Particular attention was drawn to «off-label» prescriptions; their frequency and structures. It was shown that antibiotics are common cause of serious AR among children, and their use as «off-label» prescribed drugs is an additional risk factor for such reactions.
About the Authors
A. R. Titova
Federal State Budget Institution «Informational-Methodological Center for the Expertise, Accounting and Analysis of Medical Products Circulation» under Roszdravnadzor
Russian Federation
Russian Federation
E. Y. Pasternak
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
I. L. Asetskaya
Federal State Budget Institution «Informational-Methodological Center for the Expertise, Accounting and Analysis of Medical Products Circulation» under Roszdravnadzor; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
S. K. Zyryanov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
V. A. Polivanov
Federal State Budget Institution «Informational-Methodological Center for the Expertise, Accounting and Analysis of Medical Products Circulation» under Roszdravnadzor
Russian Federation
Russian Federation
R. N. Alyautdin
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
B. K. Romanov
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Titova A.R., Pasternak E.Y., Asetskaya I.L., Zyryanov S.K., Polivanov V.A., Alyautdin R.N., Romanov B.K. ON THE SAFETY OF ANTIBACTERIAL DRUGS USED IN PEDIATRICS. Safety and Risk of Pharmacotherapy. 2015;(2):12-22. (In Russ.)
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