The Case of Сushing Syndrome in a Child of 15 Years after Prolonged Endonasal Use of Dexamethasone
S. S. Postnikov,
M. E. Karmanov,
E. V. Kuvaldina,
A. Z. Gadzhieva,
M. N. Kostyleva,
A. N. Gratsianskaya,
A. E. Ermilin https://doi.org/10.30895/2312-7821-2018-6-4-187-190
Abstract
Abstract. The article describes the case of drug Cushing syndrome as a result of prolonged (for 10 months) endonasal use of dexamethasone and oxymetazoline mixture, which was prepared by the patient’s mother. Medical control was absent. The content of dexamethasone in the vial and the concentration of oxymetazoline was not known. During the examination, in addition to Cushing syndrome, an atrophy of the nasal mucosa as a second side effect was revealed. Thus, in the above case, there were two complications of incorrect using of drugs — local and systemic.
About the Authors
S. S. Postnikov
Pirogov Russian National Research Medical University;
Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University, Moscow
Russian Federation
MD, Dr. Sci. (Med.), Professor, Professor of the Department of Clinical Pharmacology of the Pirogov Russian National Research Medical University, Clinical Pharmacologist of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
Russian Federation
MD, Dr. Sci. (Med.), Professor, Professor of the Department of Clinical Pharmacology of the Pirogov Russian National Research Medical University, Clinical Pharmacologist of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
M. E. Karmanov
Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University, Moscow
Russian Federation
Endocrinologist, Head of the Department of Endocrinology № 2 of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
Russian Federation
Endocrinologist, Head of the Department of Endocrinology № 2 of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
E. V. Kuvaldina
Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University, Moscow
Russian Federation
Endocrinologist of the Department of Endocrinology № 2 of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
Russian Federation
Endocrinologist of the Department of Endocrinology № 2 of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
A. Z. Gadzhieva
Pirogov Russian National Research Medical University;
Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University, Moscow
Russian Federation
Resident of the Department of the Clinical Pharmacology of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
Russian Federation
Resident of the Department of the Clinical Pharmacology of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
M. N. Kostyleva
Pirogov Russian National Research Medical University;
Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University, Moscow
Russian Federation
MD, Cand. Sci. (Med.), Clinical Pharmacologist, Head of the Department of the Clinical Pharmacology of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University, Associate Professor of the Department of Clinical Pharmacology of the Pirogov Russian National Research Medical University
Russian Federation
MD, Cand. Sci. (Med.), Clinical Pharmacologist, Head of the Department of the Clinical Pharmacology of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University, Associate Professor of the Department of Clinical Pharmacology of the Pirogov Russian National Research Medical University
A. N. Gratsianskaya
Pirogov Russian National Research Medical University, Moscow
Russian Federation
MD, Cand. Sci. (Med.), Clinical Pharmacologist, Associate Professor of the Department of Clinical Pharmacology of the Pirogov Russian National Research Medical University
Russian Federation
MD, Cand. Sci. (Med.), Clinical Pharmacologist, Associate Professor of the Department of Clinical Pharmacology of the Pirogov Russian National Research Medical University
A. E. Ermilin
Pirogov Russian National Research Medical University;
Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University, Moscow
Russian Federation
Assistant of the Department of Clinical Pharmacology of the Pirogov Russian National Research Medical University, Clinical Pharmacologist of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
Russian Federation
Assistant of the Department of Clinical Pharmacology of the Pirogov Russian National Research Medical University, Clinical Pharmacologist of the Russian Children’s Clinical Hospital of the Pirogov Russian National Research Medical University
References
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Review
For citations:
Postnikov S.S., Karmanov M.E., Kuvaldina E.V., Gadzhieva A.Z., Kostyleva M.N., Gratsianskaya A.N., Ermilin A.E. The Case of Сushing Syndrome in a Child of 15 Years after Prolonged Endonasal Use of Dexamethasone. Safety and Risk of Pharmacotherapy. 2018;6(4):187-190. (In Russ.) https://doi.org/10.30895/2312-7821-2018-6-4-187-190
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