The distribution of fullerene n anoparticles in the body in preclinical studies
Abstract
C60 fullerene consisting of 60 carbon atoms is a closed structure comprising 12 hexagonal and 20 pentagonal faces. The diameter of the molecule is 0.71 nm. Fullerenes are the third,after graphite and diamond carbon state. Fullerene nanoparticles are poorly absorbed from the gastrointestinal tract,therefor it is difficult to study the pattern of their distribution in the body. However,when fullerenes are administered systemically their distribution is typical for distribution of nanoparticles with the non-modified surface - the accumulation in organs containing cells of the reticuloendothelial system: the liver,spleen and lungs. A specific feature of fullerenes is their slow elimination from the body, which is primarily due to very slow metabolism of these structures.
Keywords
нанотехнологии,
фуллерены,
РЭС,
печень,
токсичность,
nanotechnology,
fullerene,
RES,
liver,
toxicity
About the Authors
R. N. Alyautdin
Федеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской Федерации
Russian Federation
Russian Federation
B. K. Romanov
Федеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской Федерации
Russian Federation
Russian Federation
V. A. Merkulov
Федеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской Федерации
Russian Federation
Russian Federation
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Review
For citations:
Alyautdin R.N., Romanov B.K., Merkulov V.A. The distribution of fullerene n anoparticles in the body in preclinical studies. Safety and Risk of Pharmacotherapy. 2015;(3):22-29. (In Russ.)
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