Clinical-pharmacological aspects of the safe use of medicines, causing prolongation of QT interval
Abstract
Specific aspects of manifestation of prolonged QT syndrome, developed during the use of drugs belonging to different pharmacological groups are discussed. It analyses data on dangerous combinations of drugs that prolong the QT interval. The combination of drugs with the possible and conditional risk of QT interval prolongation and other drugs, which can influence the activity of metabolizing isoenzymes cytochrome P450, require special care from physicians, especially in elderly patients. Taking into account the possibilities of QT prolongation due to drug interactions it is recommended to avoid the use of potentially unsafe drug combinations.
About the Authors
O. A. Demidova
Scientific Centre for Expert Evaluation of Medicinal Products
Russian Federation
Russian Federation
E. V. Shikh
Scientific Centre for Expert Evaluation of Medicinal Products; I. M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
A. D. Ismagilov
I. M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Zh. M. Sizova
I. M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Demidova O.A., Shikh E.V., Ismagilov A.D., Sizova Zh.M. Clinical-pharmacological aspects of the safe use of medicines, causing prolongation of QT interval. Safety and Risk of Pharmacotherapy. 2017;5(3):117-125. (In Russ.)
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