The paper presents a description of a rare serious adverse reaction to the phenobarbital - photosensitivity. The reaction occurred after use taking ibuprofen in a child aged 1 year. After treatment child was discharged from the hospital after 1 month.

Recommendations for preclinical safety assessment of medicinal products containing nanoparticles are presented. The recommendations provide conditions for research acute and chronic toxicity of nanotherapeutics, methods for their quantitative and qualitative assessments.

Results of the checking and correction information of standards of medical care and clinical guidelines prepared by the principal non-staff specialists of the Ministry of Health of Russia from 2012 to 2015 in terms of information about medicines are presents. The results of the analysis of typical errors when prescribing medicines are summarizes. Recommendations for the prevention and elimination of errors in the preparation of information on medicinal products are presents.