Physostigmine as an antinociceptive agent: a possible way to improve the safety of anesthesia
Abstract
Search for new safe analgesics is an urgent task that will increase the safety and efficiency of anesthesia. The aim of this study was to investigate the analgesic effect of intrathecally administered physostigmine. Antinociceptive effect was evaluated by using the method «plantar» stimulation. Administered intrathecally physostigmine caused analgesic action in the early postoperative period. Efficiency of physostigmine may be due to the influence on cholinergic links of afferent gate control system at spinal level.
References
1. Nemirovsky A, Niv D. Cholinergic Mechanisms and antinociception. In: Aronoff GM, Parris WC, Pawl RP, Raj PP, eds. Current Review of Pain. Current Science, Inc; 1996. P. 10–22, 1996.
2. Detweiler DJ, Eisenach JC, Tong C, Jackson C. A cholinergic interaction in alpha sub 2 adrenoceptor- mediated antinociception in sheep. J Pharmacol Exp Ther 1993;265:536–42.
3. Bouaziz H, Hewitt C, Eisenach JC. Spinal neostigmine potentiation of alpha sub 2- adrenergic agonist analgesia: dexmedetomidine versus clonidine. Reg Anesth 1995 in press.
4. Zhuo M, Gebhart GF. Tonic cholinergic inhibition of spinal mechanical transmission. Pain 1991; 46: 211–22.
5. Bouaziz H, Tong C, Eisenach JC. Postoperative analgesia from intrathecal neostigmine in sheep. Anesthesia & Analgesia 1995; 80: 1140–4.
6. Eisenach JC, Detweiler DJ, Tong C, D’Angelo R, Hood DD. Cerebrospinal fluid norepinephrine and acetylcholine concentrations during acute pain. Anesthesia & Analgesia 1996; 82: 621–6.
7. Yaksh T, Rudy TA. Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther 1977; 202 (2): 411–28.
8. Kraus E, Besson JM, Le Bars D. Behavioral model for diffuse noxious inhibitory controls (DNIC): potentiation by 5-hydroxytryptophan. Brain Research 1982; 231 (2): 461–5.
9. Cadden SW, Villanueva L, Chitour D, Le Bars D. Depression of activities of dorsal horn convergent neurons by propriospinal mechanisms triggered by noxious input; comparison with diffuse noxious inhibitory controls (DNIC). Brain Research 1983; 275 (1): 1–11.
10. Bouhassira D, Villanueva L, Bing Z, Le Bars D. Involvement of the subnucleus reticularis dorsalis in diffuse noxious inhibitory controls in rat. Brain Research 1992; 595 (2): 353–7.
11. Bouhassira D, Bing Z, Le Bars D. Studies of brain structures involved in diffuse noxious inhibitory controls in the rat: the rostral ventromedial medulla. Journal of Physiology 1993; 463: 667–87.
12. Morgan MM, Gogas KR, Basbaum AI. Diffuse noxious inhibitory controls reduce the expression of noxious stimulus-evoked Fos-like immunoreactivity in the superficial and deep laminae of the rat spinal cord. Pain 1994; 56 (3): 347–52.
13. Zhuo M, Gebhart GF. Inhibition of a cutaneous nociceptive reflex by a noxious visceral stimulus is mediated by spinal cholinergic and descending serotonergic systems in the rat. Brain Research 1992; 585 (1–2): 7–18.
14. Morton CR, Maisch B, Zimmermann M. Diffuse noxious inhibitory controls of lumbar spinal neurons involve a supraspinal loop in the cat. Brain research 1987; 410 (2): 347–52.
15. (DNIC) in animals and in man. Pathological physiology and experimental therapy 1992; 4: 55–65.
16. Le Bars D, Dickenson AH, Besson JM. Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurons in the rat. Pain 1979; 6 (3): 283–304.
17. Chitour D, Dickenson AH, Le Bars D. Pharmacological evidence for the involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC). Brain Research 1982; 236 (2): 329–37.
18. Men DS, Matsui Y. Activation of descending noradrenergic system by peripheral nerve stimulation. Brain Research Bulletin 1994; 34 (3): 177–82.
19. Peters ML, Schmidt AJ, Van den Hout MA, Koopmans R, Sluijter ME. Chronic back pain, acute postoperative pain and the activation of diffuse noxious inhibitory controls (DNIC). Pain 1992; 50 (2): 177–87.
20. Lewis JW, Cannon JT, Liebeskind JC. Involvement of central muscarinic cholinergic mechanisms in opioid stress analgesia. Brain Res 1983; 270: 289–293.
21. MacLennan AJ, Drugan RC, Maier SF. Long-term stress-induced analgesia blocked by scopolamine. Psychopharmacology 1983; 80: 267–268.
22. Mayer DJ, Watkins LR. Multiple endogenous opiate and nonopiate analgesia systems. Adv Pain Res Ther 1984; 6: 253–276.
Review
For citations:
Nemirovsky A. Physostigmine as an antinociceptive agent: a possible way to improve the safety of anesthesia. Safety and Risk of Pharmacotherapy. 2016;(3):22-27. (In Russ.)
Views:
1215
Email this article 