SUGGESTIONS FOR PREVENTING UNDESIRED REACTIONS AT APPLICATION IMMUNOBIOLOGICAL MEDICINAL PRODUCTS IN THE RUSSIAN FEDERATION

The authors prepared proposals for preventing undesired reactions at application immunobiological medicinal products in the Russian Federation. Given the significant number of osteitis when carrying out vaccination against tuberculosis in a nursing home as BCG and BCG-vaccine, it is proposed to consider with experts of the respective profiles of the question of the possible adjustments in the existing system of prevention of tuberculosis. To ensure timely diagnosis "BCG-ASTIC and destination specific treatment of the disease to carry out consultation with the coordinators of all children under the age of 5 years with a diagnosis of "octet" regardless of the localization of the inflammatory process. When exercising pharmacovigilance for side effects of vaccination against tuberculosis note that unlike bone tuberculosis caused by virulent bacteria, and striking in most cases, the spine, BCG osteitis virtually no this localization, and strike thigh 21, 2% of cases, tibia and fibula - 20%, sternum - 15, 6%, humerus and 11.6%, the bones of the foot is 9, 3%, fin - 8, 5%. It is considered necessary to conduct a complete replacement drugs heterologous sera, especially tetanus toxoid and rabies immunoglobulin from the serum of a horse, on preparations of human serum, as it is implemented in all developed countries. This event will lead to the exclusion of the possibility of allergic reactions of immediate type, including anaphylactic shock, when an emergency prophylaxis of these infections. Registration sterile abscesses after application of drugs DTP vaccine and the absence of such complications after the use of other adsorbed preparations (for example hepatitis In vaccines and vaccine encephalitis) do not exclude the possibility of communication first with the quality of the used sorbent and this allows us to recommend further study and evaluation of physicochemical parameters of the series of sorbent, used in the production of adsorbed vaccine containing the pertussis component.

вакцина, безопасность, нежелательная реакция, поствакцинальное осложнение, фармаконадзор, vaccine, safety, adverse reactions, post-vaccination complication, pharmacovigilance

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